Cholecystectomy is the removal of the gallbladder. It is a very common, and usually quite straightforward operation. Most patients have this done because of gallstones causing symptoms like pain. Removal or attempting to "dissolve" gallstones while leaving the gallbladder inside generally does not work. Most people after cholecystectomy return to a normal life, with no restrictions to activities or diet, and little or no long term ill effects.

Cholecystectomy is generally done laparoscopically ("key hole"). Very occasionally an open approach ("big cut") may be needed. Surgery is done under general anaesthesia ("asleep"). Some patients can go home the same day after surgery, while others stay overnight.